Insecticidal and Antifungal Activities of Aminorhodanine Derivatives | Zendy

Yoshihiko Inamori | Zendy; Yukiko Okamoto | Zendy; Yoko TAKEGAWA | Zendy; Hiroshi Tsujibo | Zendy; Yoshikazu Sakagami | Zendy; Yuko Kumeda | Zendy; Mitsunobu Shibata | Zendy; Atsushi Numata | Zendy

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Insecticidal and Antifungal Activities of Aminorhodanine Derivatives

Author(s) -

Yoshihiko Inamori,

Yukiko Okamoto,

Yoko TAKEGAWA,

Hiroshi Tsujibo,

Yoshikazu Sakagami,

Yuko Kumeda,

Mitsunobu Shibata,

Atsushi Numata

Publication year - 1998

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.62.1025

Subject(s) - trichophyton , penicillium expansum , aspergillus niger , rhodanine , candida albicans , biology , antifungal , microbiology and biotechnology , aspergillus , biochemistry , botany , postharvest

Aminorhodanine (1) showed strong insecticidal activity against Culex pipiens pallens and Musca domestica, with respective LD50 values of 0.21 microgram/insect and 0.87 microgram/insect. Compound 1 had antifungal activity against Aspergillus niger ATCC-16404, Trichophyton mentagrophytes IFO-32412, Candida albicans ATCC-10231, Hansenula anomala OPS-308 and Penicillium expansum IFO-8800. In particular, 1 had potent antifungal activity against Aspergillus niger ATCC-16404, its minimal inhibitory concentration (MIC) being 6.25 micrograms/ml. Both activities of 1 were much higher than those of rhodanine (4), suggesting that the introduction of an amino group into N-3 of 4 plays an important role in the biological activity of rhodanine-related compounds. On the other hand, N-acetylaminorhodanine (2) and N-benzoylaminorhodanine (3) did not show either activity, suggesting that the free amino group at N-3 of 1 is closely related to the inhibitory activity of rhodanine derivatives.

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