Zinc Finger-like Motif Conserved in a Family of RNA Binding Proteins | Zendy

Yuichi Matsushima | Zendy; Kiyoshi Matsumura | Zendy; Yasuo Kitagawa | Zendy

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Zinc Finger-like Motif Conserved in a Family of RNA Binding Proteins

Author(s) -

Yuichi Matsushima,

Kiyoshi Matsumura,

Yasuo Kitagawa

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.905

Subject(s) - zinc finger , structural motif , sequence motif , homologous chromosome , rna recognition motif , homology (biology) , biology , rna , conserved sequence , genetics , phd finger , computational biology , peptide sequence , rna binding protein , gene , biochemistry , transcription factor

NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys2-His2 zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.

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