Open AccessSpasmolytic Activity of Aurapten Analogs
Author(s) -
Yasumasa Yamada,
Masako Okamoto,
Hiroe Kikuzaki,
Nobuji Nakatani
Publication year - 1997
Publication title -
bioscience biotechnology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.61.740
Subject(s) - bioassay , histamine , acetylcholine , chemistry , stereochemistry , pharmacology , biology , ecology
Seven coumaric compounds analogous to aurapten were synthesized. Their spasmolytic activity against Ba2+, acetylcholine and histamine was evaluated to investigate their structure-activity relationship. The results of the bioassay demonstrated the important roles of the cis type of double bond at C-2' and the epoxide between c-6' and 7'.
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