Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D | Zendy

Masanobu Sakono | Zendy; Toshihiko Fukuyama | Zendy; Wei-Hua Ni | Zendy; Koji Nagao | Zendy; Hyang-Ran Ju | Zendy; Masao Sato | Zendy; Noriyuki Sakata | Zendy; Hisao Iwamoto | Zendy; Katsumi Imaizumi | Zendy

Open Access

Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D

Author(s) -

Masanobu Sakono,

Toshihiko Fukuyama,

Wei-Hua Ni,

Koji Nagao,

Hyang-Ran Ju,

Masao Sato,

Noriyuki Sakata,

Hisao Iwamoto,

Katsumi Imaizumi

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.514

Subject(s) - casein , cholesterol , thoracic aorta , aorta , medicine , endocrinology , chemistry , dietary protein , apolipoprotein b , tbars , food science , biochemistry , lipid peroxidation , enzyme

Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimal thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.

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