Open AccessSynthesis of Didocosahexaenoylphosphatidylserine
Author(s) -
Ruka Nakashima,
K Kado,
T Kume,
Kiyoto Maekawa
Publication year - 1997
Publication title -
bioscience biotechnology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.61.1991
Subject(s) - chemistry , amberlite , chloroform , derivative (finance) , phosphate , chloride , phosphatidylserine , serine , nuclear chemistry , salt (chemistry) , organic chemistry , medicinal chemistry , enzyme , biochemistry , phospholipid , adsorption , membrane , financial economics , economics
1,2-Di-O-isopropylideneglycerophosphorochloridate prepared from isopropylindene glycerol and phosphorus oxychloride, was allowed to react with Z-l-serine-N-phthalimidomethyl ester to obtain a derivative of phosphatidylserine. Then, after the isopropylidene group was removed by Amberlite IR-120 (H(+)), and the phosphate group was also blocked as a Ba-salt, this derivative was coupled with docosahexaenoic acid, applying the method of activated ester. Removal of both protective groups of serine was finally done by dry hydrogen chloride in chloroform.
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