Panton–Valentíne Leukocidin Genes in a Phage-like Particle Isolated from Mitomycin C-TreatedStaphylococcus aureusV8 (ATCC 49775) | Zendy

Jun Kaneko | Zendy; Takahiro Kimura | Zendy; Yoshiyuki Kawakami | Zendy; Noriko Tomita | Zendy; Yoshiyuki Kamio | Zendy

Open Access

Panton–Valentíne Leukocidin Genes in a Phage-like Particle Isolated from Mitomycin C-TreatedStaphylococcus aureusV8 (ATCC 49775)

Author(s) -

Jun Kaneko,

Takahiro Kimura,

Yoshiyuki Kawakami,

Noriko Tomita,

Yoshiyuki Kamio

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.1960

Subject(s) - panton–valentine leukocidin , leukocidin , staphylococcus aureus , integrase , recombinase , gene , microbiology and biotechnology , mitomycin c , dna , biology , bacteriophage , virology , recombination , genetics , methicillin resistant staphylococcus aureus , bacteria , escherichia coli

The staphylococcal Panton-Valentine leukocidin (PVL) genes [lukS-PV-lukF-PV] existed in a hexagonal phage-like particle (phi PVL) isolated from mitomycin C-induced Staphylococcus aureus V8 (ATCC 49775). The genome packed in phi PVL was a linear double-stranded 40-kb DNA with single-stranded cohesive ends (cos). The [lukS-PV-lukS-PV], attP, and int (integrase gene) of phi PVL were all located very close to one another within a 4.0 kb-segment on the genome in the order given, and the segment is located at the center from the left and the right cos sites. In addition, the [lukS-PV-lukF-PV]-attP-int region contains 5 direct repeat sequences that show high similarity with the recombinase-binding sites of bacteriophages of S. aureus.

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