Sequence Analysis of Functional Regions of Homoserine Dehydrogenase Genes froml-Lysine andl-Threonine-producing Mutants ofBrevibacterium lactofermentum | Zendy

Masakazu Sugimoto | Zendy; Akiko Tanaka | Zendy; Tomoko Suzuki | Zendy; Hiroshi Matsui | Zendy; Shigeru Nakamori | Zendy; Hiroshi Takagi | Zendy

Open Access

Sequence Analysis of Functional Regions of Homoserine Dehydrogenase Genes froml-Lysine andl-Threonine-producing Mutants ofBrevibacterium lactofermentum

Author(s) -

Masakazu Sugimoto,

Akiko Tanaka,

Tomoko Suzuki,

Hiroshi Matsui,

Shigeru Nakamori,

Hiroshi Takagi

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.1760

Subject(s) - threonine , mutant , lysine , brevibacterium , biology , biochemistry , homoserine , gene , amino acid , corynebacterium glutamicum , genetics , enzyme , serine , bacteria , quorum sensing , virulence , microorganism

The homoserine dehydrogenase (HD) genes from Brevibacterium lactofermentum lysine- and threonine-producing mutants were cloned, using the polymerase chain reaction, and sequenced. We found the amino acid substitutions, Val104Ile in the lysine-producing mutants in which HD may cause leaky mutation and Ser393Phe in the threonine-producing mutant with feedback-insensitive HD.

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