Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins | Zendy

Masaki Sazuka | Zendy; Hirokazu Imazawa | Zendy; Yutaka Shoji | Zendy; Takashi Mita | Zendy; Yukihiko Hara | Zendy; Mamoru Isemura | Zendy

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Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins

Author(s) -

Masaki Sazuka,

Hirokazu Imazawa,

Yutaka Shoji,

Takashi Mita,

Yukihiko Hara,

Mamoru Isemura

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.1504

Subject(s) - theaflavin , collagenase , matrix metalloproteinase , lewis lung carcinoma , chemistry , in vitro , cell culture , metastasis , microbiology and biotechnology , cancer research , biochemistry , enzyme , biology , cancer , polyphenol , genetics , antioxidant

Theaflavin and theaflavin digallate, which are components of black tea were examined by in vitro invasion assay with mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. The compounds inhibited invasion by the tumor cells. Gelatin zymography showed that the cells secreted matrix metalloproteinases (MMPs), probably including MMP-2 and MMP-9, which may be involved in tumor cell invasion and metastasis. Theaflavin and theaflavin digallate also inhibited MMPs from the culture medium of these tumor cells, as did (-)-epigallocatechin gallate. These results suggest that theaflavin, theaflavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells.

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