The Effects of Substituents Introduced into 9-Aminoacridine on Frameshift Mutagenicity and DNA Binding Affinity | Zendy

Hideyuki Tomosaka | Zendy; Saburo Omata | Zendy; Eietsu Hasegawa | Zendy; Kentaro Anzai | Zendy

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The Effects of Substituents Introduced into 9-Aminoacridine on Frameshift Mutagenicity and DNA Binding Affinity

Author(s) -

Hideyuki Tomosaka,

Saburo Omata,

Eietsu Hasegawa,

Kentaro Anzai

Publication year - 1997

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.61.1121

Subject(s) - acridine , frameshift mutation , chemistry , dna , ring (chemistry) , stereochemistry , acridine derivatives , biochemistry , mutation , organic chemistry , gene

Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.

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