The Suppressive Effect of β-Glucan on the Production of Tumor Necrosis Factor-Alpha in BV2 Microglial Cells | Zendy

Kyung Hee Jung | Zendy; MiJa Kim | Zendy; Eunyoung Ha | Zendy; Hye Kyung Kim | Zendy; Young Ock Kim | Zendy; Soon Ah Kang | Zendy; JooHo Chung | Zendy; SungVin Yim | Zendy

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The Suppressive Effect of β-Glucan on the Production of Tumor Necrosis Factor-Alpha in BV2 Microglial Cells

Author(s) -

Kyung Hee Jung,

MiJa Kim,

Eunyoung Ha,

Hye Kyung Kim,

Young Ock Kim,

Soon Ah Kang,

JooHo Chung,

SungVin Yim

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60608

Subject(s) - tumor necrosis factor alpha , lipopolysaccharide , glucan , immune system , microglia , mediator , chemistry , tumor necrosis factor α , inflammation , microbiology and biotechnology , cancer research , endocrinology , immunology , biology , biochemistry

Beta-glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. beta-Glucan decreased the production and expression of TNF-alpha. In addition, it blocked LPS-stimulated activation of nuclear factor kappa B (NF-kappaB). Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells.

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