Effect ofKluyveromyces marxianusYIT 8292 Crude Cell Wall Fraction on Serum Lipids in Normocholesterolemic and Mildly Hypercholesterolemic Subjects | Zendy

Y. Yoshida | Zendy; Eiichiro Naito | Zendy; Kenji Ohishi | Zendy; Takekazu Okumura | Zendy; Masahiko Ito | Zendy; Tadashi Sato | Zendy; Haruji Sawada | Zendy

Open Access

Effect ofKluyveromyces marxianusYIT 8292 Crude Cell Wall Fraction on Serum Lipids in Normocholesterolemic and Mildly Hypercholesterolemic Subjects

Author(s) -

Y. Yoshida,

Eiichiro Naito,

Kenji Ohishi,

Takekazu Okumura,

Masahiko Ito,

Tadashi Sato,

Haruji Sawada

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60539

Subject(s) - kluyveromyces marxianus , cholesterol , placebo , total cholesterol , kluyveromyces , chemistry , endocrinology , medicine , zoology , yeast , food science , biochemistry , biology , pathology , alternative medicine , saccharomyces cerevisiae

The hypocholesterolemic effects of Kluyveromyces marxianus YIT 8292 crude cell wall (KM-CW) were examined. In pilot studies, KM-CW tablets were administered to mildly hypercholesterolemic subjects at doses of 8.0, 4.0, 2.0, or 1.0 g/d for 4 weeks. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased at doses above 2.0 and 4.0 g/d, respectively. Further, we examined the effect of intake of yogurt containing 3.0 or 4.0 g of KM-CW/d for 8 weeks in normal and hypercholesterolemic subjects in a double-blind placebo-controlled study. The intake of either of the KM-CW-containing yogurts was associated with significantly improved TC and LDL-C in hypercholesterolemic subjects, but had no effect on these levels in normal subjects. TC was significantly lower at week 8 in the hypercholesterolemic subjects who ingested yogurt containing 3.0 or 4.0 g of KM-CW than in those who consumed placebo yogurt. Intake of KM-CW might contribute to the prevention of hypercholesterolemia.

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