Induction of Multiple Cytokine Secretion from RAW264.7 Cells by Alginate Oligosaccharides | Zendy

Yoshiko Yamamoto | Zendy; Maki Kurachi | Zendy; Kenichi Yamaguchi | Zendy; Tatsuya Oda | Zendy

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Induction of Multiple Cytokine Secretion from RAW264.7 Cells by Alginate Oligosaccharides

Author(s) -

Yoshiko Yamamoto,

Maki Kurachi,

Kenichi Yamaguchi,

Tatsuya Oda

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60416

Subject(s) - eotaxin , cytokine , tumor necrosis factor alpha , monocyte , oligomer , granulocyte macrophage colony stimulating factor , chemistry , granulocyte , secretion , macrophage inflammatory protein , interleukin , microbiology and biotechnology , immunology , chemokine , biology , biochemistry , inflammation , organic chemistry

We investigated the cytokine-inducing activities of guluronate (G3-G6) and mannuronate (M3-M6) oligomers on RAW264.7 cells with the Bio-Plex assay system. Relatively high levels of tumor necrosis factor-alpha (TNF-alpha), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), regulated upon activation normal T cell expressed and secreted (RANTES), granulocyte macrophage (GM)-CSF, and eotaxin were induced by alginate oligomers to different extents depending on the oligomer structures, and low but significant levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-9, and IL-13 were also induced. Throughout all cytokines tested, M-oligomers tended to be more potent than G-oligomers in terms of cytokine induction, and this tendency was evident in differences between G3 and M3.

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