Effects ofxapAandguaADisruption on Inosine Accumulation inEscherichia coli | Zendy

Megumi Shimaoka | Zendy; Yasuhiro Takenaka | Zendy; Yoko Mihara | Zendy; Osamu Kurahashi | Zendy; Hisashi Kawasaki | Zendy; Hiroshi Matsui | Zendy

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Effects ofxapAandguaADisruption on Inosine Accumulation inEscherichia coli

Author(s) -

Megumi Shimaoka,

Yasuhiro Takenaka,

Yoko Mihara,

Osamu Kurahashi,

Hisashi Kawasaki,

Hiroshi Matsui

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60398

Subject(s) - inosine , hypoxanthine , mutant , escherichia coli , strain (injury) , biochemistry , chemistry , biology , enzyme , gene , anatomy

A xapA-disrupted mutant was studied to minimize hypoxanthine production and to improve inosine productivity in mutants of Escherichia coli. The xapA-disrupted mutant accumulated 5.6 g/l of inosine from 40 g/l of glucose, while the parent strain accumulated 4.6 g/l. This result indicates that xapA is activated in xapA-positive inosine-producers and that xapA disruption might be useful for improving inosine productivity.

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