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A novel gene encoding a leukemic cell-killing parasporal protein, designated parasporin-4, was cloned from an isolate of Bacillus thuringiensis serovar shandongiensis. The amino acid sequence of the parasporin-4, as deduced from the gene sequence, had low-level homologies of &lt;30% with the established B. thuringiensis Cry proteins including the three known parasporins. When the gene was expressed in a recombinant of Escherichia coli BL21(DE3), the parasporin-4 formed intracellular inclusion bodies. Alkali-solubilized and proteinase K-activated inclusion protein exhibited strong cytotoxic activity against human leukemic T cells (MOLT-4) and weak for normal T cells, but no adverse effect on human uterus cervix cancer cells (HeLa).

bioscience, biotechnology, and biochemistry

Investigation of a Novel<i>Bacillus thuringiensis</i>Gene Encoding a Parasporal Protein, Parasporin-4, That Preferentially Kills Human Leukemic T Cells

Investigation of a NovelBacillus thuringiensisGene Encoding a Parasporal Protein, Parasporin-4, That Preferentially Kills Human Leukemic T Cells