Tumor Antigen Occurs inN-Glycan of Royal Jelly Glycoproteins: Honeybee Cells Synthesize T-Antigen Unit inN-Glycan Moiety | Zendy

Yoshinobu Kimura | Zendy; Takayuki Ushijima | Zendy; Megumi Maeda | Zendy; Yoichiro Hama | Zendy; Mariko Kimura | Zendy; Kiyoshi Okihara | Zendy; Hiroyuki Sugimoto | Zendy; Hideo Yamada | Zendy

Open Access

Tumor Antigen Occurs inN-Glycan of Royal Jelly Glycoproteins: Honeybee Cells Synthesize T-Antigen Unit inN-Glycan Moiety

Author(s) -

Yoshinobu Kimura,

Takayuki Ushijima,

Megumi Maeda,

Yoichiro Hama,

Mariko Kimura,

Kiyoshi Okihara,

Hiroyuki Sugimoto,

Hideo Yamada

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60331

Subject(s) - glycan , glycoprotein , oligosaccharide , moiety , antigen , galactose , residue (chemistry) , biochemistry , chemistry , biology , stereochemistry , microbiology and biotechnology , immunology

In our previous paper (Kimura, Y., et al., Biosci. Biotechnol. Biochem., 67, 1852-1856, 2003), we found that a complex type N-glycans containing beta1-3 galactose residue occurs on royal jelly glycoproteins. During structural analysis of minor components of royal jelly N-glycans, we found complex type N-glycans bearing both galactose and N-acetylgalactosamine residues. Detailed structural analysis of pyridylaminated oligosaccharide revealed that the newly found N-glycan had a complex type structure harboring a tumor marker (T-antigen) unit: Galbeta1-3GalNAcbeta1-4GlcNAcbeta1-2Manalpha1-6 (Galbeta1-3GalNAcbeta1-4GlcNAcbeta1-2Manalpha1-3) Manbeta1-4GlcNAcbeta1-4GlcNAc. To our knowledge, this may be the first report of the presence of the T-antigen unit in the N-glycan moiety of eucaryotic glycoproteins.

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