Effects of Fasting and Refeeding on Expression of Atrogin-1 and Akt/FOXO Signaling Pathway in Skeletal Muscle of Chicks | Zendy

Kazuki Nakashima | Zendy; Yoko Yakabe | Zendy; Makoto Yamazaki | Zendy; Hiroyuki Abé | Zendy

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Effects of Fasting and Refeeding on Expression of Atrogin-1 and Akt/FOXO Signaling Pathway in Skeletal Muscle of Chicks

Author(s) -

Kazuki Nakashima,

Yoko Yakabe,

Makoto Yamazaki,

Hiroyuki Abé

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60274

Subject(s) - foxo1 , medicine , endocrinology , skeletal muscle , protein kinase b , phosphorylation , signal transduction , pi3k/akt/mtor pathway , chemistry , biology , microbiology and biotechnology

This experiment was conducted to study the effects of fasting and refeeding on expression of the atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks. Chicks were fasted for 24 h and refed for 2 h. Atrogin-1 mRNA expression was increased by fasting, and their increment was reduced by refeeding. Phosphorylations of Akt and FOXO1 were not decreased by fasting, but, they were increased by refeeding. These results indicate that refeeding stimulates phosphorylation of Akt/FOXO, resulting in a decrease in atrogin-1 expression in skeletal muscle of chicks.

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