Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats | Zendy

Chang Hwa Jung | Zendy; Song Zhou | Zendy; Guo Xun DING | Zendy; Ji Hye Kim | Zendy; Myung Hee Hong | Zendy; Yong Cheol Shin | Zendy; Gyung Jun Kim | Zendy; SeongGyu Ko | Zendy

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Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

Author(s) -

Chang Hwa Jung,

Song Zhou,

Guo Xun DING,

Ji Hye Kim,

Myung Hee Hong,

Yong Cheol Shin,

Gyung Jun Kim,

SeongGyu Ko

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60238

Subject(s) - tbars , paeonia suffruticosa , streptozotocin , thiobarbituric acid , herb , traditional medicine , diabetes mellitus , chemistry , lipid peroxidation , medicine , antioxidant , medicinal herbs , biochemistry , endocrinology

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.

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