Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells | Zendy

MinYoung JI | Zendy; KangHyun Leem | Zendy; Mujo Kim | Zendy; Hye Kyung Kim | Zendy

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Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells

Author(s) -

MinYoung JI,

KangHyun Leem,

Mujo Kim,

Hye Kyung Kim

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60217

Subject(s) - alkaline phosphatase , yolk , calcification , cell growth , chemistry , medicine , endocrinology , microbiology and biotechnology , biochemistry , biology , enzyme , food science

We determined the effects of yolk water-soluble protein (YSP) on bone formation in pre-osteoblastic MC3T3-E1 cells. YSP (50-5,000 microg/ml) increased cell proliferation and collagen content. Alkaline phosphatase (ALP) activity was also increased by YSP treatment. After enhancement of ALP activity, significant augmentation of calcification was observed. These results suggest that YSP is a promising agent for the prevention and treatment of bone loss.

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