Expression of ADP-Ribosylation Factor-Like Protein 8B mRNA in the Brain Is Down-Regulated in Mice Fed a High-Fat Diet | Zendy

Tomoaki Haraguchi | Zendy; Noriyuki Yanaka | Zendy; Yoshihito Nogusa | Zendy; Naoki Sumiyoshi | Zendy; Yuko Eguchi | Zendy; Norihisa Katô | Zendy

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Expression of ADP-Ribosylation Factor-Like Protein 8B mRNA in the Brain Is Down-Regulated in Mice Fed a High-Fat Diet

Author(s) -

Tomoaki Haraguchi,

Noriyuki Yanaka,

Yoshihito Nogusa,

Naoki Sumiyoshi,

Yuko Eguchi,

Norihisa Katô

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60168

Subject(s) - messenger rna , microbiology and biotechnology , protein expression , gene expression , neurite , hek 293 cells , biology , embryonic stem cell , chemistry , gene , endocrinology , biochemistry , in vitro

A differential display was performed to analyze differential gene expression in the brains of mice in association with dietary high beef-tallow. Consumption of a high beef-tallow diet downregulated the expression of ADP-ribosylation factor-like protein 8B (Arl8B) mRNA in the brain. Arl8B mRNA was widely expressed in the mouse brain, including primary neuronal cells. The current study indicates that green fluorescent protein-fused Arl8B protein accumulated at the growth cones in primary neuronal cells, and that protrusions of human embryonic kidney 293 (HEK293) cells were significantly elongated by overexpression of Arl8B, suggesting an important role of Arl8B in neurite formation.

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