Enzymatic Synthesis ofL-Pipecolic Acid by Δ1-Piperideine-2-carboxylate Reductase fromPseudomonas putida | Zendy

Hisashi Muramatsu | Zendy; Hisaaki Mihara | Zendy; Mari Yasuda | Zendy; Makoto Ueda | Zendy; Tatsuo Kurihara | Zendy; Nobuyoshi Esaki | Zendy

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Enzymatic Synthesis ofL-Pipecolic Acid by Δ¹-Piperideine-2-carboxylate Reductase fromPseudomonas putida

Author(s) -

Hisashi Muramatsu,

Hisaaki Mihara,

Mari Yasuda,

Makoto Ueda,

Tatsuo Kurihara,

Nobuyoshi Esaki

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60125

Subject(s) - pseudomonas putida , pipecolic acid , enzyme , carboxylate , chemistry , biochemistry , amino acid

L-Pipecolic acid is a chiral pharmaceutical intermediate. An enzymatic system for the synthesis of L-pipecolic acid from L-lysine by commercial L-lysine alpha-oxidase from Trichoderma viride and an extract of recombinant Escherichia coli cells coexpressing Delta1-piperideine-2-carboxylate reductase from Pseudomonas putida and glucose dehydrogenase from Bacillus subtilis is described. A laboratory-scale process provided 27 g/l of L-pipecolic acid in 99.7% e.e.

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