Distribution and Metabolism of Dihomo-γ-linolenic Acid (DGLA, 20:3n-6) by Oral Supplementation in Rats | Zendy

Rumi UmedaSawada | Zendy; Yoko Fujiwara | Zendy; Ikuko Ushiyama | Zendy; Satoe SAGAWA | Zendy; Yasujiro Morimitsu | Zendy; Hiroshi Kawashima | Zendy; Yoshiko Ono | Zendy; Yoshinobu Kiso | Zendy; Akiyo Matsumoto | Zendy; Yousuke Seyama | Zendy

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Distribution and Metabolism of Dihomo-γ-linolenic Acid (DGLA, 20:3n-6) by Oral Supplementation in Rats

Author(s) -

Rumi UmedaSawada,

Yoko Fujiwara,

Ikuko Ushiyama,

Satoe SAGAWA,

Yasujiro Morimitsu,

Hiroshi Kawashima,

Yoshiko Ono,

Yoshinobu Kiso,

Akiyo Matsumoto,

Yousuke Seyama

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60057

Subject(s) - metabolism , distribution (mathematics) , linolenic acid , chemistry , biochemistry , medicine , endocrinology , biology , fatty acid , mathematics , linoleic acid , mathematical analysis

We compared the dietary effects of dihomo-gamma-linolenic acid (DGLA) contained in the DGLA oil produced by a fungus with gamma-linolenic acid (GLA) on the fatty acid composition. Wistar rats were fed with three kinds of oil for two weeks as follows: (i) control group: corn oil; (ii) GLA group: borage oil; (iii) DGLA group: DGLA oil/safflower oil = 55:45. The DGLA concentrations in the liver, serum, and brain of the DGLA group were higher than those of the GLA oil group. We also examined the dose effect of DGLA. The DGLA levels in the liver, serum, and brain significantly increased with increasing dosage of DGLA in the diet. DGLA administration significantly increased the ratio of PGE1/PGE2 in the rat plasma. The mechanism for GLA administration to improve atopic eczema is thought to involve an increase in the concentration of DGLA metabolized from GLA, so these results suggest that the dietary effect of DGLA would be more dominant than GLA.

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