Cyclooxygenase Induction Is Essential for NGF Synthesis Enhancement by NGF inducers in L-M Cells. | Zendy

Kohji Yamaguchi | Zendy; Tomoko Tsuji | Zendy; Daisuke Uemura | Zendy; Kiyosi Kondô | Zendy

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Cyclooxygenase Induction Is Essential for NGF Synthesis Enhancement by NGF inducers in L-M Cells.

Author(s) -

Kohji Yamaguchi,

Tomoko Tsuji,

Daisuke Uemura,

Kiyosi Kondô

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.92

Subject(s) - nerve growth factor , inducer , cyclooxygenase , chemistry , enzyme inducer , pharmacology , biology , biochemistry , enzyme , receptor , gene

Nerve growth factor (NGF) inducers, for example, 4-methylcatechol, pyrroloquinoline quinone, kansuinin A, and ingenol triacetate, stimulate NGF synthesis in L-M cells, but the mechanism of NGF induction by NGF inducers is not known. Using the four different types of previously described NGF inducers, we proved induction of cyclooxygenase activity by NGF inducers and detected prostaglandins D2 and E2 as metabolites of arachidonic acid. From the observation that the induction of NGF by each NGF inducers was inhibited by cyclooxygenase inhibitors or dexamethasone, cyclooxygenase activation is supposed to be an essential process for NGF induction.

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