Open AccessA Facile Synthesis of (R)-3-Amino-4-phenylbutyric Acid from L-Aspartic Acid
Author(s) -
Masahiko Seki,
Kazuo Matsumoto
Publication year - 1996
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.60.916
Subject(s) - aspartic acid , acylation , friedel–crafts reaction , chirality (physics) , chemistry , amino acid , stereochemistry , organic chemistry , catalysis , biochemistry , physics , chiral symmetry , quantum mechanics , nambu–jona lasinio model , quark
A practical synthesis of (R)-3-amino-4-phenylbutyric acid 1, based on Friedel-Crafts acylation with the α-aminocarboxyl group of L-aspartic acid retaining its original α-carbon chirality, is described.
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