Identification of Basic Fibroblast Growth Factor-like Immunoreactivity inPanax ginsengExtract: Investigation of Its Molecular Properties | Zendy

Yoshifumi Takei | Zendy; Toshiya Yamamoto | Zendy; Hanae Higashira | Zendy; Kensuke Hayashi | Zendy

Open Access

Identification of Basic Fibroblast Growth Factor-like Immunoreactivity inPanax ginsengExtract: Investigation of Its Molecular Properties

Author(s) -

Yoshifumi Takei,

Toshiya Yamamoto,

Hanae Higashira,

Kensuke Hayashi

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.584

Subject(s) - ginseng , basic fibroblast growth factor , isoelectric point , chemistry , fibroblast growth factor , fibroblast , pharmacology , biochemistry , growth factor , enzyme , biology , medicine , in vitro , pathology , receptor , alternative medicine

Basic fibroblast growth factor (bFGF)-like immunoreactivity was detected in extracts of Panax ginseng root by using a sensitive two-site enzyme immunoassay specific for human bFGF (hbFGF). In an investigation of the molecular properties of this bFGF-like molecule (bFGF-LI), the bFGF-LI and hbFGF were found to be equivalent with respect to antigenicity, molecular weight, isoelectric point, affinity for binding to heparin, and mitogenic activity toward BALB/c3T3 fibroblasts. The identification of this bFGF-LI molecule in Panax ginseng root helps to explain various activities of the traditional Chinese medicine ginseng.

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