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Urinary excretion of N tau-methylhistidine (MeHis) in rats was linearly elevated by starvation for 2 days. Plasma concentration of MeHis on day 1 and day 2 of starvation were increased 2.4- and 2.6-fold, respectively. The amount of released MeHis from the isolated muscles into medium during a 2-h incubation period was increased with starvation corresponded to the plasma MeHis concentration. The results of this study suggest that plasma MeHis is a sensitive index of myofibrillar protein degradation.

PlasmaNτ-Methylhistidine Concentration Is a Sensitive Index of Myofibrillar Protein Degradation during Starvation in Rats

PlasmaN^τ-Methylhistidine Concentration Is a Sensitive Index of Myofibrillar Protein Degradation during Starvation in Rats