Glycerol-3-phosphate Dehydrogenase Inhibitors, Anacardic Acids, fromGinkgo biloba | Zendy

Junko Irie | Zendy; Masatsune Murata | Zendy; Seiichi Homma | Zendy

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Glycerol-3-phosphate Dehydrogenase Inhibitors, Anacardic Acids, fromGinkgo biloba

Author(s) -

Junko Irie,

Masatsune Murata,

Seiichi Homma

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.240

Subject(s) - ginkgo biloba , salicylic acid , ginkgoales , enzyme , biochemistry , dehydrogenase , chemistry , biology , pharmacology , pharmacognosy , biological activity , in vitro

Four inhibitors of glycerol-3-phosphate dehydrogenase were isolated from Ginkgo biloba and identified as anacardic acids (6-tridecylsalicylic acid, 6-[(8Z)-pentadecenyl]salicylic acid, 6-[(9Z,12Z)-heptadecadienyl]salicylic acid, and 6-[(8Z)-heptadecenyl]salicylic acid) by instrumental analyses. Their 50% inhibitory concentrations against the enzyme were 1-3 μg/ml under the standard assay conditions. Anacardic acid inhibited the enzyme non-competitively. The sarcotesta contained most of anacardic acids, and nuts a little.

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