Antimutagenic Effects of Ajoene, an Organosulfur Compound Derived from Garlic | Zendy

Keiko Ishikawa | Zendy; Rie Naganawa | Zendy; Hisae YOSHIDA | Zendy; Nami Iwata | Zendy; Hiroyuki Fukuda | Zendy; Tsuchiyoshi Fujino | Zendy; Atsushi Suzuki | Zendy

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Antimutagenic Effects of Ajoene, an Organosulfur Compound Derived from Garlic

Author(s) -

Keiko Ishikawa,

Rie Naganawa,

Hisae YOSHIDA,

Nami Iwata,

Hiroyuki Fukuda,

Tsuchiyoshi Fujino,

Atsushi Suzuki

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.2086

Subject(s) - organosulfur compounds , s9 fraction , mutagenesis , chemistry , biochemistry , microsome , enzyme , mutation , organic chemistry , gene , sulfur

The antimutagenic effects of ajoene, which is an organosulfur compound derived from garlic, were investigated by the Ames test. Ajoene inhibited mutagenesis induced by both benzo[a]pyrene (B[a]P) and 4-nitro-1,2-phenylenediamine (NPD) in a dose-dependent manner. In particular, NPD-induced mutagenesis was more effectively suppressed by ajoene than the B[a]P-induced type. Furthermore, the inhibition of mutagenesis by ajoene was more effective for transition-type mutations than for the frame shift type. HPLC analysis of B[a]P metabolism in the presence of the rat liver microsomal fraction (S-9) showed that ajoene dose-dependently inhibited the metabolic activation of B[a]P. This suggests that ajoene affected the metabolic enzymes in the S-9 fraction.

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