Nicardipine and Nifedipine Inhibit Fatty Acid Desaturases in Rat Liver Microsomes | Zendy

Hiroshi Kawashima | Zendy; Kengo Akimoto | Zendy; Saeree Jareonkitmongkol | Zendy; Norifumi Shirasaka | Zendy; Sakayu Shimizu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nicardipine and Nifedipine Inhibit Fatty Acid Desaturases in Rat Liver Microsomes

Author(s) -

Hiroshi Kawashima,

Kengo Akimoto,

Saeree Jareonkitmongkol,

Norifumi Shirasaka,

Sakayu Shimizu

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.1672

Subject(s) - nicardipine , nifedipine , cinnarizine , verapamil , microsome , pharmacology , chemistry , diltiazem , flunarizine , biochemistry , biology , calcium , in vitro , organic chemistry

Nicardipine and nifedipine, Ca channel blockers, inhibited rat liver microsomal desaturases, though verapamil, methoxyverapamil, cinnarizine, flunarizine, and diltiazem did not. However, nicardipine and nefidipine apparently did not inhibit the fungal desaturation in Mortierella alpina 1S-4. Nicardipine inhibited rat liver microsomal delta 5 desaturase specifically (50% inhibitory concentration. 170 microM), and nifedipine inhibited delta 6 desaturase specifically (78 microM). The inhibition by nicardipine and nifedipine is uncompetitive, the Ki values for delta 5 and delta 6 desaturases being 62 and 44 microM, respectively.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research