Efficientl-Serine Production from Methanol and Glycine by Resting Cells ofMethylobacteriumsp. Strain MN43 | Zendy

Tairo Hagishita | Zendy; Toyokazu Yoshida | Zendy; Yoshikazu Izumi | Zendy; Toshio Mitsunaga | Zendy

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Efficientl-Serine Production from Methanol and Glycine by Resting Cells ofMethylobacteriumsp. Strain MN43

Author(s) -

Tairo Hagishita,

Toyokazu Yoshida,

Yoshikazu Izumi,

Toshio Mitsunaga

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.1604

Subject(s) - methylobacterium , glycine , serine , methylotroph , methanol , bacteria , strain (injury) , chemistry , facultative , microorganism , biosynthesis , biochemistry , amino acid , biology , organic chemistry , botany , enzyme , 16s ribosomal rna , genetics , anatomy , gene

Resting cells of methanol-utilizing microorganisms isolated from soils were examined for L-serine production under conditions in which L-serine-degradation was suppressed. Strain MN43, a facultative methylotrophic bacterium identified as a Methylobacterium sp., was selected for further studies. Under the optimal conditions, 65 mg/ml L-serine was produced by this bacterium from 50 mg/ml glycine and 104 mg/ml methanol in 5 days, with a molar conversion ratio from glycine to L-serine of 93%. This production is the highest so far reported for microbes producing L-serine.

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