Angiotensin I-Converting Enzyme Inhibitors in Autolysates of Squid Liver and Mantle Muscle | Zendy

Yutaka Wako | Zendy; Satoru Ishikawa | Zendy; Koji Muramoto | Zendy

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Angiotensin I-Converting Enzyme Inhibitors in Autolysates of Squid Liver and Mantle Muscle

Author(s) -

Yutaka Wako,

Satoru Ishikawa,

Koji Muramoto

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.1353

Subject(s) - autolysis (biology) , mantle (geology) , inhibitory postsynaptic potential , enzyme , chemistry , biochemistry , renin–angiotensin system , angiotensin converting enzyme , ic50 , squid , biology , endocrinology , in vitro , fishery , paleontology , blood pressure

Autolysis of squid liver and mantle muscle homogenates, and blends of both, each yielded inhibitory activity toward the angiotensin I-converting enzyme. The inhibitory activity and the amount of solubilized protein in each of these autolysates were examined over a period of 24 h. Inhibitory peptides were isolated from the mixed autolysate, their structures (IC50) being Tyr-Ala-Leu-Pro-His-Ala (9.8 microM) and Gly-Tyr-Ala-Leu-Pro-His-Ala (27.3 microM).

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