Fate of Nicotinamide Differs Due to an Intake of Nicotinamide | Zendy

Katsumi Shibata | Zendy; Shimada Hisako | Zendy; Hiroshi Taguchi | Zendy

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Fate of Nicotinamide Differs Due to an Intake of Nicotinamide

Author(s) -

Katsumi Shibata,

Shimada Hisako,

Hiroshi Taguchi

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.1204

Subject(s) - nicotinamide , metabolite , niacin , toxicity , catabolism , chemistry , catabolite repression , limiting , excretion , endocrinology , medicine , metabolism , biochemistry , biology , mechanical engineering , mutant , engineering , gene , enzyme , organic chemistry

We found that the catabolism of nicotinamide (Nam) differs due to an intake of Nam itself in rats. When rats were fed with a Nam-free, tryptophan-limiting diet, the major catabolite of niacin was N1-methyl-4-pyridone-3-carboxamide (4-Py). However, its percentage was changed with increasing the intake of Nam. The major metabolite was N1-methylnicotinamide (MNA) in the diet containing 0.006% Nam, or 0.1% Nam. The toxicity of excess Nam was observed when rats were fed with a 0.5% Nam-containing diet. In this diet, the major metabolite was Nam N-oxide and it was noted that the urinary excretion of nicotinic acid and its metabolite nicotinuric acid was observed. Therefore, these acids might be detected only when the toxicity of Nam appears.

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