Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase fromGeotrichumsp. WF9101 | Zendy

Moir Tatsuma | Zendy; Michio SAKIMOTO | Zendy; Kagi Takashi | Zendy; Sakai Takuo | Zendy

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Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase fromGeotrichumsp. WF9101

Author(s) -

Moir Tatsuma,

Michio SAKIMOTO,

Kagi Takashi,

Sakai Takuo

Publication year - 1996

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.60.1191

Subject(s) - geotrichum , enantioselective synthesis , alcohol dehydrogenase , chemistry , enantiomer , dehydrogenase , enzyme , nad+ kinase , alcohol , enantiomeric excess , organic chemistry , diol , stereochemistry , catalysis , food science

Geotrichum sp. WF9101 could degrade (S)-( + )-l,2-propanediol, (S)-( + )-l,3-butanediol, and (2S,4S)-( # )-2,4-pentanediol, but not the corresponding enantiomers. An NAD(+)-linked secondary alcohol dehydrogenase purified from the strain showed the same enantio-selective oxidations towards these diols. This enzyme is proposed to be useful for the preparation of (R)-( - )-diols from the racemates of these diols.

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