Open AccessA New Cytotoxic Compound from a Water Extract of Corn
Author(s) -
Yoshiki Hayashi,
Ishihara Nobuhiro,
Takahashi Motohisa,
Fujii Eiji,
Uenakai Kazuo,
Masada Shinichi,
Ichimoto Itsuo
Publication year - 1996
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.60.1115
Subject(s) - cytotoxic t cell , chemistry , stereochemistry , cytotoxicity , biochemistry , in vitro
A new cytotoxic compound 2 was isolated from a water extract of corn germ. Structural elucidation by spectroscopic data and chemical evidence fully substantiated 2 to be 11 (E)-10-oxo-11-octadecen-13-olide. Compound 2 exhibited considerably strong cytotoxic activity against various cell lines with IC50 of 0.9-2.8 micrograms/ml.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom