Conversion Ratio of Tryptophan to Niacin in Rats Fed with a Nicotinic Acid-free, Tryptophan-limiting Diet | Zendy

Katsumi Shibata | Zendy

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Conversion Ratio of Tryptophan to Niacin in Rats Fed with a Nicotinic Acid-free, Tryptophan-limiting Diet

Author(s) -

Katsumi Shibata

Publication year - 1995

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.59.715

Subject(s) - tryptophan , niacin , limiting , tryptophan metabolism , nicotinic agonist , chemistry , biochemistry , amino acid , mechanical engineering , receptor , engineering

The effects of amino acid composition on the conversion ratio of Trp to niacin in rats were investigated. The ratio in the group fed with a nicotinic acid-free, 9% casein-sucrose diet (basal diet) was 3.5%. This ratio was statistically decreased to 0.2% by the addition of 2% glycine, 0.078% L-threonine, and 0.2% L-cystine, and restored to 3.2% by the further addition of 0.1% tryptophan. From these results and our previous findings, it was considered that Trp imbalance might be a manifestation of niacin deficiency.

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