Open AccessAntihypertensive Effects of Peptide in Sake and Its By-products on Spontaneously Hypertensive Rats
Author(s) -
Yoshiyuki Saito,
Keiko Wanezaki,
Akitsugu Kawato,
Satoshi Imayasu
Publication year - 1994
Publication title -
bioscience, biotechnology, and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.58.812
Subject(s) - hydrolysate , blood pressure , medicine , endocrinology , spontaneously hypertensive rat , peptide , pharmacology , chemistry , biochemistry , hydrolysis
Systolic blood pressure (SBP) decreased significantly when the hydrolysate of sake lee (HSL) and peptide fraction of sake (PFS) were orally administrated to spontaneously hypertensive rats (SHR). SBP of "young" SHR decreased significantly after orally administering Val-Tyr, His-Tyr, Arg-Phe, Val-Trp, and Tyr-Trp that were isolated from PFS and HSL. The hypotensive effect of Val-Tyr and His-Tyr that was observed in "young" SHR disappeared as they got older, but PFS and HSL maintained their antihypertensive effect on "aged" SHR. SHR fed on a diet with HSL replacing half of the protein source for 3 weeks showed a significant decrease in SBP after 10 days of feeding.