Polyphenolic Constituent Structures ofZanthoxylum piperitumFruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-ResistantStaphylococcus aureus | Zendy

Miwako Kusuda | Zendy; Kazutoshi Inada | Zendy; Tomo-omi Ogawa | Zendy; Takashi Yoshida | Zendy; Sumiko Shiota | Zendy; Tomofusa Tsuchiya | Zendy; Tsutomu Hatano | Zendy

Open Access

Polyphenolic Constituent Structures ofZanthoxylum piperitumFruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-ResistantStaphylococcus aureus

Author(s) -

Miwako Kusuda,

Kazutoshi Inada,

Tomo-omi Ogawa,

Takashi Yoshida,

Sumiko Shiota,

Tomofusa Tsuchiya,

Tsutomu Hatano

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.50669

Subject(s) - zanthoxylum , staphylococcus aureus , chemistry , proanthocyanidin , polyphenol , rutaceae , minimum inhibitory concentration , antibiotics , antibacterial activity , methicillin resistant staphylococcus aureus , chromatography , microbiology and biotechnology , traditional medicine , bacteria , biochemistry , biology , botany , medicine , genetics , antioxidant

Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan. Our study found that ZP-CT-A, a polymeric proanthocyanidin purified from the fruit of this species, noticeably decreased the minimum inhibitory concentrations of beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus (MRSA). The structure of ZP-CT-A was characterized on the basis of (13)C NMR and size exclusion chromatographic data and the results of thiolytic degradation. A mechanistic study of the effects of ZP-CT-A indicated that it suppressed the activity of beta-lactamase and largely decreased the stability of the bacterial cell membrane of MRSA, as shown by a reduction in the tolerance of MRSA to low osmotic pressure and high ionic strength solutions.

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