Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product | Zendy

Teruyuki Usui | Zendy; Hirohito Watanabe | Zendy; Fumitaka Hayase | Zendy

Open Access

Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product

Author(s) -

Teruyuki Usui,

Hirohito Watanabe,

Fumitaka Hayase

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.50584

Subject(s) - methylglyoxal , glycation , glyceraldehyde , chemistry , advanced glycation end product , lactoylglutathione lyase , biochemistry , derivative (finance) , product (mathematics) , enzyme , receptor , geometry , mathematics , financial economics , economics , dehydrogenase

We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and N(alpha)-acetylarginine. A major product was identified as N(alpha)-acetyl-N(delta)-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.

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