Inhibitory Effects of Pasuchaca (Geranium dielsiaum) Extract on α-Glucosidase in Mouse | Zendy

Mariko Karato | Zendy; Kohji Yamaguchi | Zendy; Shin Takei | Zendy; Takao Kino | Zendy; Kazunaga Yazawa | Zendy

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Inhibitory Effects of Pasuchaca (Geranium dielsiaum) Extract on α-Glucosidase in Mouse

Author(s) -

Mariko Karato,

Kohji Yamaguchi,

Shin Takei,

Takao Kino,

Kazunaga Yazawa

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.50420

Subject(s) - maltase , maltose , alpha glucosidase , inhibitory postsynaptic potential , carbohydrate , sucrose , starch , chemistry , blood sugar , oral administration , in vitro , geranium , pharmacology , traditional medicine , endocrinology , diabetes mellitus , biology , medicine , biochemistry , enzyme , botany , cultivar

The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on alpha-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.

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