γ-Mangostin fromGarcinia MangostanaPericarps as a Dual Agonist That Activates Both PPARα and PPARδ | Zendy

Nobuyasu Matsuura | Zendy; Kanae Gamo | Zendy; Hiroyuki Miyachi | Zendy; Munekazu Iinuma | Zendy; Teruo Kawada | Zendy; Nobuyuki Takahashi | Zendy; Yukihiro Akao | Zendy; Hideki Tosa | Zendy

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γ-Mangostin fromGarcinia MangostanaPericarps as a Dual Agonist That Activates Both PPARα and PPARδ

Author(s) -

Nobuyasu Matsuura,

Kanae Gamo,

Hiroyuki Miyachi,

Munekazu Iinuma,

Teruo Kawada,

Nobuyuki Takahashi,

Yukihiro Akao,

Hideki Tosa

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130541

Subject(s) - garcinia mangostana , peroxisome proliferator activated receptor , reporter gene , agonist , chemistry , ppar agonist , peroxisome , carnitine , receptor , pharmacology , biochemistry , endocrinology , gene expression , biology , gene , medicine , traditional medicine

We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that γ-mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

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