Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats | Zendy

Chihiro Imai | Zendy; Tomomi Harazaki | Zendy; Seiya Inoue | Zendy; Kazuki Mochizuki | Zendy; Toshinao Goda | Zendy

Open Access

Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats

Author(s) -

Chihiro Imai,

Tomomi Harazaki,

Seiya Inoue,

Kazuki Mochizuki,

Toshinao Goda

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130451

Subject(s) - postprandial , endocrinology , medicine , inflammation , tumor necrosis factor alpha , peripheral , dipeptidyl peptidase 4 , s100a9 , type 2 diabetes , insulin , diabetes mellitus , receptor

Treatment with the dipeptidyl peptidase-4 inhibitor, anagliptin, or with the α-glucosidase inhibitor, miglitol, reduced the oral sucrose load-inducible expression of interleukin (IL)-1β, IL-18, tumor necrosis factor-α, S100a8, S100a9, S100a11, IL-1R2, IL-1Rn and tumor necrosis factor receptor 2 genes in peripheral leukocytes of Otsuka Long-Evans Tokushima fatty (OLETF) rats at the stage of impaired glucose tolerance. Inhibiting postprandial hyperglycemia reduced the expression of genes related to inflammation in peripheral leukocytes of OLETF rats.

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