Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6 | Zendy

Sho Matsui | Zendy; Takumi Yamane | Zendy; Kazuo Kobayashi | Zendy; Yuichi Oishi | Zendy

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Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6

Author(s) -

Sho Matsui,

Takumi Yamane,

Kazuo Kobayashi,

Yuichi Oishi

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130450

Subject(s) - calcitonin gene related peptide , calcitonin , serum amyloid a , peptide , endocrinology , medicine , chemistry , amyloid (mycology) , interleukin , messenger rna , antibody , gene expression , calcitonin receptor , interleukin 6 , gene , neuropeptide , immunology , biology , inflammation , cytokine , biochemistry , receptor , inorganic chemistry

We found that calcitonin gene-related peptide (CGRP) enhanced the expression of levels of serum amyloid A (SAA) and interleukin-6 (IL-6) in HepG2. In addition, CGRP-induced SAA1/2 mRNA expression was blocked by an anti-IL-6 neutralizing antibody in HepG2. These results suggest that CGRP promotes SAA synthesis through activation of IL-6 in human hepatocytes.

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