A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice | Zendy

IChing Hou | Zendy; Yasuyuki Oi | Zendy; Hiroyuki Fujita | Zendy; Yoshihisa Yano | Zendy; Harukazu Fukami | Zendy; Masaaki Yoshikawa | Zendy

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A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

Author(s) -

IChing Hou,

Yasuyuki Oi,

Hiroyuki Fujita,

Yoshihisa Yano,

Harukazu Fukami,

Masaaki Yoshikawa

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130298

Subject(s) - capsaicin , hair growth , chemistry , pharmacology , black tea , ic50 , traditional medicine , endocrinology , receptor , food science , medicine , in vitro , biochemistry , physiology

Chinese black tea extract (CBTE) fermented with Aspergillus sp. significantly promoted hair growth after 2 weeks of topical application in shaved 6 week-old male C3H/He mice. The hair growth-promoting effect of CBTE was potentiated synergistically by capsaicin, which has no effect on hair growth by itself. CBTE displayed an affinity for estrogen receptor (ER)α, with an IC50 value of 74.8 µg/mL. This effect of CBTE might be mediated by the ERs, since a similar effect induced by orally administered soy isoflavone, a mixture of ERs ligands, has been reported to be synergistically potentiated by capsaicin.

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