Isolation and Structural Determination of Makinolide B fromStreptomycessp. MK-19 | Zendy

Michitaka Hidaki | Zendy; Mitsuru Yoshida | Zendy; Naoto Ogawa | Zendy; Shinya Kodani | Zendy

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Isolation and Structural Determination of Makinolide B fromStreptomycessp. MK-19

Author(s) -

Michitaka Hidaki,

Mitsuru Yoshida,

Naoto Ogawa,

Shinya Kodani

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130204

Subject(s) - heteronuclear single quantum coherence spectroscopy , streptomyces , staphylococcus aureus , stereochemistry , antibacterial activity , chemistry , isolation (microbiology) , agar diffusion test , two dimensional nuclear magnetic resonance spectroscopy , microbiology and biotechnology , biology , bacteria , genetics

A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100 µg/disk.

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