Changes in NAD Content Induced by Nicotinic Acid-Related Compounds in K562 Cells during Differentiation | Zendy

Chieri Ida | Zendy; Shin Ogata | Zendy

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Changes in NAD Content Induced by Nicotinic Acid-Related Compounds in K562 Cells during Differentiation

Author(s) -

Chieri Ida,

Shin Ogata

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.130131

Subject(s) - isonicotinic acid , nad+ kinase , nicotinic agonist , nicotinamide , chemistry , niacin , nicotinamide adenine dinucleotide , biochemistry , nicotinic acids , enzyme , organic chemistry , receptor , hydrazide

Two nicotinic acid-related compounds were found to induce erythroid differentiation in K562 cells. We investigated the changes in nicotinamide adenine dinucleotide (NAD) content induced by nicotinic acid-related compounds during differentiation. The NAD content was reduced by a treatment with nicotinic acid and isonicotinic acid. These results provide important clues toward elucidating the erythroid differentiation mechanism.

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