Medium-Chain Fatty Acids Enhanced the Excretion of Fecal Cholesterol and Cholic Acid in C57BL/6J Mice Fed a Cholesterol-Rich Diet | Zendy

Qing Xu | Zendy; Xue Chang-yong | Zendy; Zhang Yong | Zendy; Yinghua Liu | Zendy; Jin Wang | Zendy; Xiaoming Yu | Zendy; Xinsheng Zhang | Zendy; Rongxin Zhang | Zendy; Xueyan Yang | Zendy; Changjiang Guo | Zendy

Open Access

Medium-Chain Fatty Acids Enhanced the Excretion of Fecal Cholesterol and Cholic Acid in C57BL/6J Mice Fed a Cholesterol-Rich Diet

Author(s) -

Qing Xu,

Xue Chang-yong,

Zhang Yong,

Yinghua Liu,

Jin Wang,

Xiaoming Yu,

Xinsheng Zhang,

Rongxin Zhang,

Xueyan Yang,

Changjiang Guo

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120999

Subject(s) - cholic acid , cholesterol , excretion , bile acid , cholesterol 7 alpha hydroxylase , chemistry , medicine , feces , triglyceride , endocrinology , stearic acid , fatty acid , deoxycholic acid , biochemistry , biology , microbiology and biotechnology , organic chemistry

The objective of the present study was to investigate the cholesterol-reducing effect of medium-chain fatty acids (MCFAs) completed by elevated excretion of fecal neutral steroids and/or bile acids. Blood and liver lipid profiles, fecal neutral steroids, bile acids, and mRNA and protein expression of the genes relevant to cholesterol homeostasis were measured and analyzed in C57BL/6J mice fed a cholesterol-rich diet with 2% caprylic acid or capric acid for 12 weeks. Blood total cholesterol and low-density lipoprotein cholesterol (LDL-c) levels were reduced significantly as compared to diet with palmitic acid or stearic acid. Caprylic acid promoted the excretion of fecal neutral steroids, especially cholesterol. The excretion of fecal bile acids, mainly in the form of cholic acid was enhanced and accompanied by elevated expression of mRNA and the protein of hepatic cholesterol 7α-hydroxylase (CYP7A1). These results indicate that MCFAs can reduce blood cholesterol by promoting the excretion of fecal cholesterol and cholic acid.

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