Versatility of Enzymes Catalyzing Late Steps in Polyene 67-121C Biosynthesis | Zendy

Niamh Stephens | Zendy; Bernard J. Rawlings | Zendy; Patrick Caffrey | Zendy

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Versatility of Enzymes Catalyzing Late Steps in Polyene 67-121C Biosynthesis

Author(s) -

Niamh Stephens,

Bernard J. Rawlings,

Patrick Caffrey

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120961

Subject(s) - polyene , biosynthesis , atp synthase , biochemistry , enzyme , cytochrome p450 , streptomyces , polyketide synthase , disaccharide , gene , gene cluster , biology , chemistry , stereochemistry , genetics , polyketide , bacteria

Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.

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