Plausible Novel Ribose Metabolism Catalyzed by Enzymes of the Methionine Salvage Pathway inBacillus subtilis | Zendy

Toshihiro Nakano | Zendy; Y. SAITO | Zendy; Akiho Yokota | Zendy; Hiroki Ashida | Zendy

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Plausible Novel Ribose Metabolism Catalyzed by Enzymes of the Methionine Salvage Pathway inBacillus subtilis

Author(s) -

Toshihiro Nakano,

Y. SAITO,

Akiho Yokota,

Hiroki Ashida

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120932

Subject(s) - bacillus subtilis , dephosphorylation , enzyme , ribose , biochemistry , chemistry , methionine , nucleotide salvage , isomerization , metabolism , metabolic pathway , catalysis , stereochemistry , biology , phosphatase , amino acid , bacteria , nucleotide , genetics , gene

The methionine salvage pathway (MSP) recycles reduced sulfur from 5-methylthioribose. Here we propose a novel ribose metabolic pathway performed by MSP enzymes of Bacilli. MtnK, an initial catalyst of MSP, had significant ribose kinase activity, with Vmax and Km values of 2.9 µmol min(-1) mg of protein(-1) and 4.8 mM. Downstream enzymes catalyzed the isomerization of ribose-1-phosphate and subsequent dehydration, enolization, dephosphorylation, and dioxygenation.

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