ManR, a Transcriptional Regulator of the β-Mannan Utilization System, Controls the Cellulose Utilization System in Aspergillus oryzae | Zendy

Masahiro Ogawa | Zendy; Tetsuo Kobayashi | Zendy; Yasuji Koyama | Zendy

Open Access

ManR, a Transcriptional Regulator of the β-Mannan Utilization System, Controls the Cellulose Utilization System in <i>Aspergillus oryzae</i>

Author(s) -

Masahiro Ogawa,

Tetsuo Kobayashi,

Yasuji Koyama

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120795

Subject(s) - aspergillus oryzae , cellulase , regulator , gene , mannan , enzyme , biology , dna , transcriptional regulation , gene expression , microbiology and biotechnology , biochemistry , polysaccharide

ManR, a DNA-binding protein possessing the Zn(II)(2)Cys(6) binuclear cluster domain, acts as a positive regulator of mannanolytic enzyme genes in Aspergillus oryzae. In this study, we found that ManR controlled the expression not only of mannanolytic enzyme genes but also of cellulolytic enzyme genes in A. oryzae, based on DNA microarray analysis of a manR-disruptant and a manR-overexpressing strain. A new model for the regulation of cellulase and hemicellulase genes mediated by ManR and XlnR in A. oryzae is proposed.

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