Increased Tyrosine in the Brain and Serum of Mice by Orally Administering Dipeptide SY | Zendy

Kayoko Esaki | Zendy; Taketo Ohmori | Zendy; Motohiro Maebuchi | Zendy; Toshihiro Nakamori | Zendy; Toshihisa Ohshima | Zendy; Shigeki Furuya | Zendy

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Increased Tyrosine in the Brain and Serum of Mice by Orally Administering Dipeptide SY

Author(s) -

Kayoko Esaki,

Taketo Ohmori,

Motohiro Maebuchi,

Toshihiro Nakamori,

Toshihisa Ohshima,

Shigeki Furuya

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120747

Subject(s) - dipeptide , oral administration , orally active , pharmacology , tyrosine , medicine , bioavailability , chemistry , peptide , biochemistry

We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

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