New 3-O-Alkyl-4a,10a-dihydrofusarubins Produced by Fusarium sp. Mj-2 | Zendy

Masanobu Suzuki | Zendy; Naoto Nishida | Zendy; Atsushi Ishihara | Zendy; Hiromitsu Nakajima | Zendy

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New 3-<i>O</i>-Alkyl-4a,10a-dihydrofusarubins Produced by <i>Fusarium</i> sp. Mj-2

Author(s) -

Masanobu Suzuki,

Naoto Nishida,

Atsushi Ishihara,

Hiromitsu Nakajima

Publication year - 2013

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.120670

Subject(s) - metabolite , alkyl , substituent , fusarium , strain (injury) , antifungal , stereochemistry , antimicrobial , chemistry , derivative (finance) , biology , microbiology and biotechnology , organic chemistry , biochemistry , botany , anatomy , financial economics , economics

Five new 3-O-alkyl-4a,10a-dihydrofusarubins (2-6) were isolated from the culture filtrate of a strain of Fusarium sp. (Mj-2), together with the known metabolite, anhydrofusarubin (1). The structures of the new metabolites were elucidated by spectroscopic analyses to be 3-O-butyl, 3-O-3'-methylbutyl, 3-O-2'-methylbutyl and 3-O-2'-phenylethyl-4a,10a-dihydrofusarubin A, and an isomer of 3-O-2'-phenylethyl-4a,10a-dihydrofusarubin A. Their antifungal and antibacterial activities were evaluated together with a 3-O-methyl derivative (7) prepared from 3-O-butyl-4a,10a-dihydrofusarubin A (2), indicating that the size of the O-substituent at C-3 in the 4a,10a-dihydrofusarubins negatively affected the metabolites' antimicrobial activity.

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